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Ati Pharmacology Made Easy Pain and Inflammation Test Answers

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Review

doi: 10.1186/ar116. Epub 2000 Jul 20.

Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs

Affiliations

  • PMID: 11094452
  • PMCID: PMC130140
  • DOI: 10.1186/ar116

Free PMC article

Review

Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs

J Steinmeyer . Arthritis Res. 2000 .

Free PMC article

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the mechanism of action of NSAIDs and, in this context, clinical findings on NSAID-induced gastrointestinal side effects are summarized. This knowledge is important for the effective treatment of pain and inflammation, as well as for preventing serious and sometimes lethal gastrointestinal side effects.

Figures

Figure 1
Figure 1

Regulation of prostaglandin biosynthesis by cyclo-oxygenase-1 and cyclo-oxygenase-2 [16].

Figure 2
Figure 2

Physiological and pathophysiological functions of cyclo-oxygenase-2. Modified according to [15].

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Source: https://pubmed.ncbi.nlm.nih.gov/11094452/

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